• In conjunction with decreased mean

  2019-07-06

  

  In conjunction with decreased mean shortening velocity, vertebrate cardiac aging is characterized by a prolongation of systolic contraction time [8,[50], [51], [52]]. The Drosophila heart similarly displays increasingly longer systolic intervals with advancing age [23,44]. The mechanistic basis of t

• At this point it is at least clearly

  2019-07-05

  

  At this point, it is at least clearly known that O-GlcNAcylation plays a significant role in AD pathophysiology which makes this post-translational modification an attractive target to tackle this devastating neurodegenerative disease. Using a pharmacological approach to modulate O-GlcNAcylation in

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