br A Shakeri Zadeh Investigating the
A. Shakeri-Zadeh, Investigating the photo-thermo-radiosensitization eﬀects of fo-late-conjugated gold nanorods on KB nasopharyngeal carcinoma cells, Photodiagnosis Photodyn. Ther. 24 (2018) 324–331.
 A. Neshastehriz, M. Tabei, S. Maleki, S. Eynali, A. Shakeri-Zadeh, Photothermal therapy using folate conjugated gold nanoparticles enhances the eﬀects of 6 MV X-ray on Etoposide epidermal carcinoma cells, J. Photochem. Photobiol. B, Biol. 172 (2017) 52–60.
 W. Feng, W. Nie, C. He, X. Zhou, L. Chen, K. Qiu, W. Wang, Z. Yin, Eﬀect of pH-responsive alginate/chitosan multilayers coating on delivery eﬃciency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers, ACS Appl. Mater. Interfaces 6 (11) (2014) 8447–8460.
M. Mirrahimi, et al.
H.C. Park, A. Deorukhkar, R.J. Staﬀord, S.H. Cho, Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy, Nano Lett. 8 (5) (2008) 1492–1500.
 L. Wang, X. Lin, J. Wang, Z. Hu, Y. Ji, S. Hou, Y. Zhao, X. Wu, C. Chen, Novel insights into combating cancer chemotherapy resistance using a plasmonic nano-carrier: enhancing drug sensitiveness and accumulation simultaneously with loca-lized mild photothermal stimulus of femtosecond pulsed laser, Adv. Funct. Mater. 24 (27) (2014) 4229–4239.
Available online at www.sciencedirect.com
A translational approach to design effective intervention tools for informal caregivers of dependent cancer patients
a Universidad Catolica de Valencia, Guillem de Castro, 175, 46008, Valencia, Spain
b Servicio Oncologı´a Hospital - Fundacion General Valencia, Universidad de Valencia, Medicina, Avenida Tres Cruces, 2, 46014, Spain
Dependent cancer patients
Quality of life
Objectives: Caregivers of terminal patients often report a higher prevalence of unmet needs than cancer survivors. However, very few interventions have been carried out to support caregivers of patients in advanced stages, and, in most cases, internodes have not been rigorously designed and evaluated. The ultimate aim of this research was to obtain specific infor-mation about the sociodemographic characteristics, the different types of care provided, the symptoms due to burdens, the impact of caring on the quality of life, and the unmet needs of informal caregivers of dependent patients with cancer. This is to design effective intervention programs that can be implemented from the hospital setting itself and therefore, to improve their quality of life and prevent the deterioration of their health.
Study design: A cross-sectional design and survey methodology were used for descriptive purposes.
Methods: The sample was composed of 132 informal caregivers of dependent patients with cancer, from a public hospital in Valencia, Spain, who were identified through the patient database of the oncology service, over the 4-month data collection period. Self-administered questionnaires were combined with personal interviews: Interview Proto-col for the main caregiver, Questionnaire ICUB97, and survey of hospital quality.
Results: The most frequently provided types of care included the following: keeping the patient company, acting as an intermediary between them and healthcare workers, and helping them to do basic daily life activities. The main negative consequences caregivers reported were the following: feeling more tired, having less free time, changing their daily routines, and having fewer social relationships/interactions and various emotional and physical symptoms. Many of the needs of informal caregivers were not being met: reso-lution of doubts about illness, training in the care they should provide to the patient, and psychological help.